Influence Of Binding Solution Concentration, Drying Duration And Drying Temperature On Physiochemical Performance Of Norfloxacin Granules And Tablets

Objective: To investigate the possible individual and joined influences that binding solution concentration, drying temperature and drying duration might have on the physiochemical attributes of granules and tablets using norfloxacin as a model drug. Methods: According to implemented 23 central composite designs, each of the investigated variables were examined at 5 different levels through different 16 formulation runs. For each formulation, obtained granules were qualified for their bulk density, tap density, Hausner ratio, percent of fine and drug content properties whereas the respective tablets were evaluated for their weight variation, drug content, friability, hardness, disintegration, and drug dissolution attributes. Results: Indicated that concentration of binder solution, as compared to drying temperature and drying duration, measured more profound influences on granules' tap density, Hausner ratio, % fine and drug content either through its individual linear and quadratic effects or through its joint effect with drying durations (p<0.05 at 95% CI for all influences). Whilst tablets' friability appeared to be noticeably influenced by the three investigated variables (P ranged 0.001-0.017 at 95% CI), tablets' hardness and disintegration were found to be considerably affected only by binder solution concentration (p = 0.001 and 0.082 at 95% CI, respectively). Moreover, none of the investigated variables has measured a significant influence on tablets' drug content or drug dissolution properties. Conclusion: The study concluded that quadratic and joint influences of variables on attributes of granule and tablet formulations shouldn't be overlooked and better to be considered in the screening design.

Effect of different temperatures on viability of seven encysted metacercariae recovered from freshwater fishes in Qualyobia, Egypt

Encysted metacercariae [EMC] from seven trematod-zoonotic parasites were exposed to different temperature mechanisms. Boiling of the infected fishes was sufficient to kill the EMC, frying of fishes for five minutes was quite sufficient to inhibit the viability of EMC, but frying for 10 minutes killed all EMC. Grilling of infected Tilapia zillii was sufficient to kill EMC after 10 minutes; however five minutes were sufficient only to kill EMC in Clarias gariepinus. Regarding chilling at 5°C, T. zillii EMC showed variation in response. Complete loss of viability of Prohemistomatidae EMC was achieved after 14 days, for Haplorchidae after 11 days, for Diplostomatidae after 12 days, while Clinostomatidae EMC required 15 days. For Cl. gariepinus, Bagrus bajad and Chrysichthys auratus achieved results were similar to those for T. zillii but with fewer days of withstanding chilling. The EMC infecting Tilapia lost their viability by freezing at -5 °C and -10 °C for Prohemistomatidae after 48 and 40 hours, for Diplostomatidae after 24 and 16 hours and for Clinostomatidae cysts after 48 and 32 hours respectively. In infected Clarias gariepinus, Bagrus bajad and Chrysichthys auratus the EMC lost their viability by fireezing at -5 °C and -10 °C for periods shorter than those of Tilapia sp

Metacercariae recovered from fresh-water fishes in the vicinity of Qualkyobia Governorate, Egypt

A total of 410 Tilapia zillii, 70 Clarias gariepinus, 30 Bagrus bajad and 15 Chlrysichthys auratus fishes were collected from different water bodies in Qualyobia Governorate. Microscopic examination of samples showed infection in muscles and head region [gills and branchial cavity] with encysted metacercariae in 91.7% of T. zillii, 82.85% of Cl. gariepinus, 70% of B. bajad and 86.66% of Ch. auratus. The highest distribution of metacercarial infection among the T. zillii was in the muscles of posterior third and tail followed by the middle third, anterior third and head region [gills and branchial cavity] while the highest distribution of metacercarial infection among Cl. gariepinus was in the middle third muscles followed by the posterior third, anterior third and lastly in the head region. The highest metacercarial infection among B. bajad and Ch. auratus fish was in the posterior third muscles and branchial cavity respectively. The taxonomic morphology of the encysted metacercariae and the excysted ones was given